Pharmacology

Pharmacology is the science of drugs. It is derived from Greek word pharmacon meaning drug and logos meaning discourse in. Two integral part of pharmacology are :

Pharmacodynamics(physiological and biochemical effects of drugs and their mechanism of action)-mechanism of action, combined effect of drugs, drug dosage, factor modifying drug action. 

Pharmacokinetics(is the quantitative study of drug movement)- absorption, distribution, binding/ localization/ storage, biotransformation and excretion of the drug. 

Drugs can be administered by Local routes(topical, deeper tissues i.e intraarticular, intrathecal , retrobulbar and arterial supply). Systemic routes (oral, sublingual, rectal, cutaneous, inhalation, nasal and parenteral i.e intramuscular, intravenous or intradermal. Patients should be carefully screened for clinical evidence of hemodynamic and cardiac pathology before larger-volume liposuction is undertaken, as it may result in unnecessary high risk for patients who have preexisting cardiovascular disorders.. 

Tumescent liposuction totally by local anesthesia has proven to be extremely safe despite the use of unprecedented large doses of lidocaine and epinephrine. The explanation for this remarkable safety is the extreme dilution of the tumescent local anesthetic solution.. Various studies have suggested that tumescent anesthesia with a total lidocaine dose of up to 55 mg/kg is safe for use in liposuction.